1. Angle test with WATER was conducted before and after applying the coating and observed contact angles of 22.3 and 92.1, respectively. What does this tell you about the hydrophilicity/hydrophobicity of the coating compared to the implant?
a. The coating is more hydrophobic
b. The implant is more hydrophobic
c. Cannot tell hydrophilicity/hydrophobicity from test
d. The coating is more hydrophilic
e. The coating and implant have similar hydrophilicity/hydrophobicity
2. (0.075pts) Protein adsorption is governed by thermodynamics in which the enthalpy and entropy of the entire system are evaluated to determine whether or not protein adsorption is favorable or unfavorable. If adsorption reduces G for one or more components of the system with minimal increase in G for another component, protein adsorption will
a. not occur
b. occur spontaneously
c. not enough information to determine outcome
3. (0.075pts) In terms of protein structure terminology, the tertiary structure of a protein refers to:
a. The 3D arrangement of primary structures
b. The 3D arrangement of secondary structures
c. The 3D arrangement of subunits (separate protein chains)
d. The local intrachain interactions to form 3D structures (e.g. alpha-helix or beta-pleated sheet)
4. (0.075pts) True/False: Broadly speaking, ceramics are the most resistant to degradation compared to polymeric and metallic materials
a. True
b. False
5. (0.075pts) Based on the initial water-in-air contact angle (table to the right), what polymer would you estimate to be the most hydrophobic. NOTE: Disregard the standard deviations; ONLY consider the mean for the purposes of this question.
a. pSTS1:1:0.5
b. pSTS2:1:1
c. pSCS1:1:2
d. They are all very hydrophobic
6. (0.075pts) Which of the following protein adsorption behavior does the Langmuir model describe?
a. Reversible binding of proteins to substrate
b. Irreversible binding of proteins to substrate
c. Restructuring of proteins
d. Multi-layer formation