H H L-Proline H- ? Acetone 4 HO H H 0 H 0 H HO HO === Isomerization ?? 0 H Isobutyraldehyde HO Enamine H (1) (2) H. H (3A) 00 H H HO Chair conformation with axial group-not favored H Q 00 H H Chair conformation with equatorial group-favored (3B)
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