1) What is Dosage compensation as it relates to sex chromosomes?
2) What is the Lyon's Hypothesis? Who is Mary Lyon?
3) What is a Calico Cat? How does one of these cats look? What has happened to their X chromosomes to make them look that way?
4) Explain why you cannot typically have a Male Calico cat.
5) Can you think of any unusual situation where you might be able to have a Male Calico cat? Explain how this might occur.
6) Explain how X-chromosome inactivation takes place in mammals at the chromosomal and molecular level. What genes are involved in inactivating an X chromosome?
7) Why aren't Turner's females, who have one X chromosome, phenotypically normal, given that males only have one X and are normal, and all female mammals inactivate one of their 2 X chromosomes, leaving them with one X, just like Turner's females? These females are also normal, but Turner's females are not normal. Why?