00:01
In order to convert cyclohexane into adipic acid, we're going to need a step that will break the ring open.
00:07
And a likely candidate for that would be ozonolysis because we're making a product with two aldehydes in it.
00:19
So if we start at the end and work backwards and think about an ozonolysis reaction, reaction, so ozone followed by zinc and water or dimethyl sulfide as a reductive workup.
00:51
The starting material we would need for that would be cyclohexane.
00:56
So the question is how can we get from cyclohexane to cyclohexane? cyclohexane is a hydrocarbon, so it doesn't have many reactions available to it so about the only useful one we could use would be radical substitution we can put a bromine onto the ring and then to get from bromo cyclohexane to cyclohexene we would just need to eliminate the bromide so perhaps treatment with potassium hydroxide and heat and that would give kbr as a byproduct where hbr would be a byproduct on the first reaction so the second synthesis is similar conceptually we're making a racemic mixture of epoxides or or oxycyclopropanes, and they have a trans geometry in the, as far as the methyl groups are concerned.
02:43
So we can get that product composition if we start with butyene in the e configuration, and to make the epoxides, we would use a peroxy acid...