Question

2. Reflux a) What is the reason for using a CaCl2 drying tube in the reflux setup? Draw a general reaction scheme to support your answer. (4 pts) b) What is the reflux temperature of the Knoevenagel-Transesterification reaction? Briefly explain your answer. (4 pts) 3. Mechanism and Interpretation a) Draw a detailed mechanism, using curved arrow notation, for the synthesis of ethyl coumarin-3-carboxylate, starting from the intermediate Knoevenagel condensation product. (6 pts) b) In the attached 1H NMR spectrum of ethyl-3-coumarincarboxylate, draw the structure on the spectrum and assign the various resonances (peaks) to the hydrogen nuclei responsible for them. (4 pts) PPM

          2. Reflux
a) What is the reason for using a CaCl2 drying tube in the reflux setup? Draw a general reaction scheme to support your answer. (4 pts)
b) What is the reflux temperature of the Knoevenagel-Transesterification reaction? Briefly explain your answer. (4 pts)
3. Mechanism and Interpretation
a) Draw a detailed mechanism, using curved arrow notation, for the synthesis of ethyl coumarin-3-carboxylate, starting from the intermediate Knoevenagel condensation product. (6 pts)
b) In the attached 1H NMR spectrum of ethyl-3-coumarincarboxylate, draw the structure on the spectrum and assign the various resonances (peaks) to the hydrogen nuclei responsible for them. (4 pts)
PPM

2. Reflux
a) What is the reason for using a CaCl2 drying tube in the reflux setup? Draw a general reaction scheme to support your answer. (4 pts)
b) What is the reflux temperature of the Knoevenagel-Transesterification reaction? Briefly explain your answer. (4 pts)
3. Mechanism and Interpretation
a) Draw a detailed mechanism, using curved arrow notation, for the synthesis of ethyl coumarin-3-carboxylate, starting from the intermediate Knoevenagel condensation product. (6 pts)
b) In the attached 1H NMR spectrum of ethyl-3-coumarincarboxylate, draw the structure on the spectrum and assign the various resonances (peaks) to the hydrogen nuclei responsible for them. (4 pts)
PPM

Added by Zachary E.

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