Question

2) (11 points) When blood glucose is low, the liver converts acetyl CoA to ?-hydroxybutyrate according to the following reaction: 2 + NADH + H?O ? CoA OH O + 2 CoA + NAD? a) (4 points) Considering only ?-oxidation, what are the requirements and products if eicosenoic acid (20:1?¹¹), one of the main fatty acids of hemp oil, is used as the starting product for ?- oxidation? b) (2 points) Assume that all acetyl CoA from ?-oxidation is converted into ?-hydroxybutyrate. How many molecules of ?-hydroxybutyrate are made and how much NADH is required? c) (5 points) Use the results from above to determine the overall yield of NADH and FADH?. If the NADH and FADH? are oxidized using mitochondrial electron transport, what is the typical ATP yield that can be obtained in the liver from the conversion of eicosenoic acid to ?-hydroxybutyrate? Don't forget to include any ATP/ATP equivalents produced or consumed in the overall process.

          2) (11 points) When blood glucose is low, the liver converts acetyl CoA to ?-hydroxybutyrate
according to the following reaction:
2
+ NADH + H?O ?
CoA
OH
O
+ 2 CoA + NAD?
a) (4 points) Considering only ?-oxidation, what are the requirements and products if eicosenoic
acid (20:1?¹¹), one of the main fatty acids of hemp oil, is used as the starting product for ?-
oxidation?
b) (2 points) Assume that all acetyl CoA from ?-oxidation is converted into ?-hydroxybutyrate. How
many molecules of ?-hydroxybutyrate are made and how much NADH is required?
c) (5 points) Use the results from above to determine the overall yield of NADH and FADH?. If the
NADH and FADH? are oxidized using mitochondrial electron transport, what is the typical ATP
yield that can be obtained in the liver from the conversion of eicosenoic acid to ?-hydroxybutyrate?
Don't forget to include any ATP/ATP equivalents produced or consumed in the overall process.

2) (11 points) When blood glucose is low, the liver converts acetyl CoA to ?-hydroxybutyrate
according to the following reaction:
2
+ NADH + H?O ?
CoA
OH
O
+ 2 CoA + NAD?
a) (4 points) Considering only ?-oxidation, what are the requirements and products if eicosenoic
acid (20:1?¹¹), one of the main fatty acids of hemp oil, is used as the starting product for ?-
oxidation?
b) (2 points) Assume that all acetyl CoA from ?-oxidation is converted into ?-hydroxybutyrate. How
many molecules of ?-hydroxybutyrate are made and how much NADH is required?
c) (5 points) Use the results from above to determine the overall yield of NADH and FADH?. If the
NADH and FADH? are oxidized using mitochondrial electron transport, what is the typical ATP
yield that can be obtained in the liver from the conversion of eicosenoic acid to ?-hydroxybutyrate?
Don't forget to include any ATP/ATP equivalents produced or consumed in the overall process.

Added by Marilyn M.

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