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Hello everyone, the question says which of the following statements concerning the process of spontaneous folding of proteins is not true? 24.
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For the purpose of spontaneous folding of protein, we can analyze each statement.
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Option a, it may be defective in some of the human diseases.
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This is true as misfolded proteins can lead to diseases like parkinson's.
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Option b, it usually an essential random process.
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It is false as protein folding is not entirely random.
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It flows a specific pathway guided by the amino acid sequence and interaction between amino acids.
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Option c, it may involve initial formation of local secondary structure.
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This is true as secondary structures like alpha, helix and beta sheets often form first during protein folding.
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Option d, that is it may involve gradually decreasing range of conformational species.
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This is true as the protein enfolds the number of possible conformational species.
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Option e, it is possible to involve initial formation of the highly compact state.
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This is true as some proteins are common for compact interdependent state before reaching their final folding structure.
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So, the statement that is not true is option b...