Question

26. After intravenous and oral administration of 500 mg of a drug to a healthy young volunteer the following data are obtained: Time (min) Plasma Concentration (g/mL) Oral tablet IV 0.50 3.13 0.80 3.04 0.95 2.95 1.08 2.71 1.04 2.48 0.96 2.27 0.81 1.91 0.68 1.60 0.48 1.13 0.34 0.80 0.24 0.56 0.17 0.40 5 10 15 30 45 60 90 120 180 240 300 360 No drug is recovered in the urine of this volunteer, and plasma protein binding is negligible Calculate the following pharmacokinetic parameters of the drug: - Elimination rate constant, k. - Elimination half-life, t: - Volume of distribution, V - Clearance, CL - Intrinsic clearance, CLim (4BC) - Bioavailability, F - Absorption rate constant, k.

          26. After intravenous and oral administration of 500 mg of a drug to a healthy young volunteer the following data are obtained:
Time (min)
Plasma Concentration (g/mL) Oral tablet IV 0.50  3.13 0.80 3.04 0.95 2.95 1.08 2.71 1.04 2.48 0.96 2.27 0.81 1.91 0.68 1.60 0.48 1.13 0.34 0.80 0.24 0.56  0.17 0.40
5 10 15 30  45 60 90 120 180 240 300 360
No drug is recovered in the urine of this volunteer, and plasma protein binding is negligible
Calculate the following pharmacokinetic parameters of the drug:
- Elimination rate constant, k.
- Elimination half-life, t:
- Volume of distribution, V
- Clearance, CL
- Intrinsic clearance, CLim (4BC)
- Bioavailability, F
- Absorption rate constant, k.

26 after intravenous and oral administration of 500 mg of a drug to a healthy young volunteer the following data are obtained time min plasma concentration gml oral tablet iv 050 313 080 304 09707

Added by Nicholas G.

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