1. (6 pts) Label the relationship between the highlighted...

1. (6 pts) Label the relationship between the highlighted substituents as homotopic, enantiotopic or diastereotopic.\ H$_3$C CH$_3$\ H\\ Br\ Me\ CH$_3$\ Me$_2$\ H$_3$C\ Br\ Me\ Me\ HO\ Me\ 2. (2 pts) Circle the appropriate stereochemical descriptor for the highlighted groups.\ HO\ H H\ H H\ $\uparrow$\ Pro-R or Pro-S\ Pro-R or Pro-S

Transcript

00:01 Hello everyone, let's look at the question.

00:03 So here a molecule is given where the two substrents are present.

00:07 Okay, and we are asked to say or write whether the two groups are sister or sisters to each other or trans to each other and which arrangement is more stable.

00:18 Okay.

00:18 And the given molecule is a cyclohexene molecule and in this substants are tertiary butal group ch3.

00:40 So this is ch3 okay and at third position another ch3 is there hydrogen so this is the given molecule and now we have to write whether it is cis to each other or trans to each other and the most stable one okay okay so here the most stable arrangement is so we know that the cyclohexene it is it is present in chair conformer okay so most of the cycle hexane they will present in chair conformer only.

01:15 So the most stable one is, so this is one of the chair confirmer and here we can see that the both groups are they are bulkier one.

01:26 Okay and in case of chair confirmer two positions will be there.

01:29 One is exhale and the one is the equatorial.

01:32 Now if you consider axial position, so if the bulkier groups are present in axle position, then that will be one three dioxide interaction.

01:40 Okay, so due to one three dioxide interaction, molecule will become unstable.

01:44 So that's why the bulkier groups will reside in equatoral position.

01:48 Now if you consider these two, so one is tertiary betyle group, one is another one is the methyl group and both are what are bulky groups only...

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