00:01
The question here talks of poor therapies.
00:11
Floro, uracil, timo, solomite, setucemap and pemehtrext.
00:36
We are to find out that which of these targeted therapies walks through signal transduction inhibition, starting with fluoroboracil.
01:08
Florolysis causes binding of deoxyribonucleotides, drnts of the drug and folate cofactor to the enzyme thymidylate synthase forming a ternary complex.
01:45
Thus, poro -uracil causes inhibition in the synthesis of dna or rna.
01:56
The next one is tamozolamide.
02:03
Temozolamide is a dna alkylating agent.
02:19
It causes cell cycle arrest at the g2m transition and thus initiates apoptosis...