________ receptors are involved in long-term potentiation. dopamine GABA NMDA serotonin
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Fill in the blanks to correctly complete the following description of long-term potentiation (LTP) (0.5 pts each): LTP is induced by ___________ stimulation of a neuron, such as when an animal learning a task. LTP refers to the fact that after repeated stimulation, the postsynaptic neuron shows ___________ responses for many minutes or even hours. In the early phase of LTP, repeated stimulation of the presynaptic neuron results in the release of the neurotransmitter ___________. Receptors for this transmitter are of two different kinds, called ___________ and ___________, which play key roles in the synaptic mechanism of LTP. One of these receptor types is normally inactivated because it is bound by the ___________ ion. Increased neurotransmitter release initially causes the ___________ receptors to mediate more ___________ of the postsynaptic membrane, which upon reaching threshold, results in ejecting the blocking ions from the ___________ receptors. Now that this receptor type is no longer blocked, these receptors add to the responsiveness of the postsynaptic neuron. They do so because they now act as ion channels that allow ___________ ions to enter the cell, activating several proteins, which increase the ___________ of existing ___________ receptors at the postsynaptic membrane, as well as recruiting more of them through trafficking from inside the cell. During the late phase of LTP, several kinases that had been activated earlier, in turn activate the transcription factor ___________ which turns on the expression of many ___________ involved in long-lasting structural changes in the synapse that sustain its modified level of activity.
Supreeta N.
Danielle F.
At many synapses in the hippocampus, long-term potentiation depends on the activation of NMDA receptors which have affinities for and respond to: - glutamate - norepinephrine - GABA - dopamine - nitric oxide Question 27 Based on imaging research of the brain, the region known as DLPFC (dorsolateral prefrontal cortex) is associated with: - spatial tasks - executive control - verbal tasks - all of the above - none of the above
Suman K.
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