Question

A patient receiving procainamide therapy for cardiac arrhythmia is given an IV loading dose resulting in a serum concentration of 6 µg/mL. The therapeutic range is 4-8 µg/mL and the half-life is 4 hours. Four hours after the initial loading dose, another equivalent dose is given as an IV bolus resulting in a serum concentration of 7.5 µg/mL. Does the serum concentration after the second dose seem appropriate? If not, what would be the predicted serum concentration at this time? What factors would influence the rate of elimination of this drug?

          A patient receiving procainamide therapy for cardiac arrhythmia is given an IV loading dose resulting in a serum concentration of 6 µg/mL. The therapeutic range is 4-8 µg/mL and the half-life is 4 hours. Four hours after the initial loading dose, another equivalent dose is given as an IV bolus resulting in a serum concentration of 7.5 µg/mL. Does the serum concentration after the second dose seem appropriate? If not, what would be the predicted serum concentration at this time? What factors would influence the rate of elimination of this drug?

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