Question

A protein binds to a ligand with a ka of 2.9 x 10^5 M^-1s^-1 and a kd of 1.8 x 10^-2 s^-1. What is the molar concentration of ligand when Y is 0.75? 1.9 x 10^-7 6.2 x 10^-8 insufficient information to solve 4.8 x 10^7 Question 20 (5 points) Which of the following is CORRECT regarding protein misfolding and aggregation? Protein misfolding occurs only following accumulation of folding intermediates; it never results from misfolding of an already correctly folded protein. The propensity of proteins to aggregate in cells decreases following increased expression of cellular proteins. The formation of ordered aggregates via amyloidogenesis (of fibrillization) proceeds with an overall decrease in protein secondary structure. The specific activity, or reactivity, of misfolded proteins, expressed as the number of reactive sites per mg of total protein, decreases with the extent of fibrillization.

          A protein binds to a ligand with a ka of 2.9 x 10^5 M^-1s^-1 and a kd of 1.8 x 10^-2 s^-1. What is the molar concentration of ligand when Y is 0.75?

1.9 x 10^-7
6.2 x 10^-8
insufficient information to solve
4.8 x 10^7

Question 20 (5 points)

Which of the following is CORRECT regarding protein misfolding and aggregation?

Protein misfolding occurs only following accumulation of folding intermediates; it never results from misfolding of an already correctly folded protein.
The propensity of proteins to aggregate in cells decreases following increased expression of cellular proteins.
The formation of ordered aggregates via amyloidogenesis (of fibrillization) proceeds with an overall decrease in protein secondary structure.
The specific activity, or reactivity, of misfolded proteins, expressed as the number of reactive sites per mg of total protein, decreases with the extent of fibrillization.

A protein binds to a ligand with a ka of 2.9 x 10^5 M^-1s^-1 and a kd of 1.8 x 10^-2 s^-1. What is the molar concentration of ligand when Y is 0.75?

1.9 x 10^-7
6.2 x 10^-8
insufficient information to solve
4.8 x 10^7

Question 20 (5 points)

Which of the following is CORRECT regarding protein misfolding and aggregation?

Protein misfolding occurs only following accumulation of folding intermediates; it never results from misfolding of an already correctly folded protein.
The propensity of proteins to aggregate in cells decreases following increased expression of cellular proteins.
The formation of ordered aggregates via amyloidogenesis (of fibrillization) proceeds with an overall decrease in protein secondary structure.
The specific activity, or reactivity, of misfolded proteins, expressed as the number of reactive sites per mg of total protein, decreases with the extent of fibrillization.

Added by Mar C.

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