00:01
Hello everyone, in this question we have been asked about the clotting cascade.
00:06
So, we need to tell that the clotting cascade involves.
00:10
So, the plasma clotting cascade consists of a series of reaction that involves the activation of xynogen that is inert precursors of the enzymes via the limited proteolysis and the resulting enzymes are catalytically active serine proteolysis yet they have low inherent enzymatic activity as isolated proteins.
00:35
So, there are many types of the clotting factors like factor 1 that is the fibrinogen, factor 2 that is prothrombin, factor 3 that is tissue thromboplastin or tissue factor, then factor 4 that is ionized calcium, factor 5 that is labile factor or proxelerin, then factor 7 that is stable factor or pro -converting and factor 8 that is anti -haemophilic factor.
01:03
So, prothrombin is also known as factor 2, this is the blood clotting normally occurs when there is damage to the blood vessel.
01:12
So, this is majorly involved in the clotting cascade and platelets immediately begin to adhere to the cut edges of the vessel and release the chemicals to extract even more platelets and a platelet plug is formed and the external bleeding stops.
01:27
So, a coagulation cascade refers to the series of the steps that occur during the formation of blood clot after injury by activating a cascade of protein that is called the clotting factor.
01:39
So, there are three stages of the blood clotting, first is the constriction, then the second step is the formation of temporary platelet plug and the third is the activation of the coagulation cascade.
01:58
So, erythroprotein is associated with changes in blood coagulation and febrile lysis.
02:04
It transients during the initial months of therapy and after correction of anemia.
02:10
So, there are certain reports that suggest that growing incidence of symptomatic venous thrombosis in cancer patients treated with recombinant erythropoietin.
02:20
So, several investigators have reported on different mechanism of thrombosis in these patients.
02:27
So, erythropoietin basically stimulates the red blood cell production...