Aspirin and ibuprofen are relatively_____ moleccules that can bind to the Active site of ______. In contrast inhibitors such as celecoxib are relatively ____ molecules That bind____
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Step 1: Aspirin and ibuprofen are relatively small molecules that can bind to the active site of COX (cyclooxygenase). Show more…
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6. Selective inhibition of the COX-2 isoform is often more desirable than non-selective inhibition of both COX-1 and COX-2. Which of the following statements best describes how NSAIDs can exploit COX-2 selectivity? (2 points) a. COX-2 has smaller hydrophobic amino acid residues at the 434 and 523 positions essentially making the active site larger b. COX-2 has only 75% amino acid identity to COX-1, therefore the non-identical 25% is completely utilized to achieve selectivity c. NSAIDs are COX-2 irreversible inhibitors (also known as mechanism-based and suicide inhibitors) and simple competitive COX-1 inhibitors d. The COX-1 active site solely contains hydrophobic residues, therefore selective COX-2 NSAIDs are hydrophilic 7. In the active site, which of the following amino acids are important for COX recognition of arachidonic acid? (Select all correct answers) (2 points) a. R b. H c. Y d. I e. W f. C g. V h. A 8. Aspirin is an irreversible non-selective COX inhibitor. Which of the following is true about how aspirin inhibits COX-1? (Select all correct answers) (2 points)
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