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Biochemistry: Answering Questions about a Pentapeptide 1. A pentapeptide has the sequence of HN-Glu-His-Leu-Arg-Gly-COOH. a) What is the net charge of the peptide at pH 3, 8, and 11? (Use pKa values for side chains and terminal amino and carboxyl groups in the table provided. 15 pts.) b) Estimate the pI for this peptide. (5 pts.) pKa values Abbreviation/ pKa, pKa, pKa Amino acid symbol Mr (COOH) NHS (R group) Nonpolar, aliphatic R groups Glycine Gly G 75 2.34 9.60 Alanine Ala A 89 2.34 9.69 Proline Pro P 115 1.99 10.96 Valine Val V 117 2.32 9.62 Leucine Leu L 131 2.36 9.60 Isoleucine Ile I 131 2.36 8.96 Methionine Met M 149 2.28 9.21 Aromatic R groups Phenylalanine Phe F 165 1.83 Tyrosine Tyr Y 181 2.20 9.11 10.07 Tryptophan Trp W 204 2.38 9.39 Polar, uncharged R groups Serine Ser S 105 2.21 9.15 Threonine Thr T 119 2.11 9.62 Cysteine Cys C 121 1.96 10.28 8.18 Asparagine Asn N 132 2.02 8.88 Glutamine Gln Q 146 2.17 9.13 Positively charged R groups Lysine Lys K 146 2.18 8.95 10.53 Histidine His H 155 1.82 9.17 6.00 Arginine Arg R 174 2.17 9.04 12.48 Negatively charged R groups Aspartate Asp D 133 1.88 9.60 3.65 Glutamate Glu E 147 2.19 9.67 4.25 Hydropathy Occurrence in index* proteins% 5.97 6.01 6.48 5.97 5.98 6.02 5.74 1.8 1.6 4.2 3.8 4.5 1.9 7.2 7.8 5.2 6.6 9.1 5.3 2.3 5.48 5.66 5.89 2.8 -1.3 -0.9 3.9 3.2 1.4 5.68 5.87 5.07 5.41 5.65 -0.8 -0.7 2.5 -3.5 -3.5 6.8 5.9 1.9 4.3 4.2 9.74 7.59 10.76 -3.9 -3.2 -4.5 5.9 2.3 5.1 2.77 3.22 -3.5 3.5 5.3 6.3

          Biochemistry: Answering Questions about a Pentapeptide

1. A pentapeptide has the sequence of HN-Glu-His-Leu-Arg-Gly-COOH.

a) What is the net charge of the peptide at pH 3, 8, and 11? (Use pKa values for side chains and terminal amino and carboxyl groups in the table provided. 15 pts.)

b) Estimate the pI for this peptide. (5 pts.)

pKa values Abbreviation/ pKa, pKa, pKa Amino acid symbol Mr (COOH) NHS (R group) Nonpolar, aliphatic R groups Glycine Gly G 75 2.34 9.60 Alanine Ala A 89 2.34 9.69 Proline Pro P 115 1.99 10.96 Valine Val V 117 2.32 9.62 Leucine Leu L 131 2.36 9.60 Isoleucine Ile I 131 2.36 8.96 Methionine Met M 149 2.28 9.21 Aromatic R groups Phenylalanine Phe F 165 1.83 Tyrosine Tyr Y 181 2.20 9.11 10.07 Tryptophan Trp W 204 2.38 9.39 Polar, uncharged R groups Serine Ser S 105 2.21 9.15 Threonine Thr T 119 2.11 9.62 Cysteine Cys C 121 1.96 10.28 8.18 Asparagine Asn N 132 2.02 8.88 Glutamine Gln Q 146 2.17 9.13 Positively charged R groups Lysine Lys K 146 2.18 8.95 10.53 Histidine His H 155 1.82 9.17 6.00 Arginine Arg R 174 2.17 9.04 12.48 Negatively charged R groups Aspartate Asp D 133 1.88 9.60 3.65 Glutamate Glu E 147 2.19 9.67 4.25

Hydropathy Occurrence in index* proteins%
5.97 6.01 6.48 5.97 5.98 6.02 5.74
1.8 1.6 4.2 3.8 4.5 1.9
7.2 7.8 5.2 6.6 9.1 5.3 2.3
5.48 5.66 5.89
2.8 -1.3 -0.9
3.9 3.2 1.4
5.68 5.87 5.07 5.41 5.65
-0.8 -0.7 2.5 -3.5 -3.5
6.8 5.9 1.9 4.3 4.2
9.74 7.59 10.76
-3.9 -3.2 -4.5
5.9 2.3 5.1
2.77 3.22
-3.5 3.5
5.3 6.3

biochemistryplease answer the asked below 1 a pentapeptide has the sequence of hn glu his leu arg gly coohawhat is the net charge of the peptide at ph 38and 11use pka values for side chains 51577

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