Question

Cell membrane AFM probe tip $\alpha$ $a$ $r$ $\delta$ $u_z$

          Cell membrane
AFM probe tip
$\alpha$
$a$
$r$
$\delta$
$u_z$

Added by Abigail V.

University Physics with Modern Physics

Hugh D. Young 14th Edition

Instant Answer

Solved by Expert Kratika Bhadauria

Step 1

We are given the cone half-angle for an AFM probe tip (30°) and the assumption that the cell is incompressible. To start, we need to understand the relationship between the contact diameter and the modulus of the cell. In AFM, the contact diameter is determined Show more…

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(c) Plot the contact diameter (i.e., twice the radius) versus the modulus of the cell for 1, 10, 100, and 1000 pN, the range of forces that are typically applied to cells with AFM. Assume that the cone half-angle for an AFM probe tip is 30Â° and that the cell is incompressible (i.e., the cell volume does not change when it is deformed by the AFM probe tip). You will find it clearer to use a log-log plot for this question. (d) Show on your plot the typical range of cell moduli and applied forces and use this to determine how large an area is indented by the AFM probe tip. This defines the lateral resolution that can be expected for an elasticity map. Is this resolution adequate? Why or why not? **Please explain how to go about graphing in part C. I feel as though there is missing information for variables such as the Poisson ratio.