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(c) You are tasked with designing composite 3D printed alginate/PCL scaffolds for a tissue engineering application (Fig Q1c). The compressive moduli of the alginate hydrogel and PCL polymer are 50 kPa and 60 MPa, respectively. i. Estimate how much alginate and PCL should be included in the scaffold (in relative terms) to match native compressive modulus of articular cartilage (2 MPa). State all assumptions you make for your estimation. ii. Based on your scaffold design, estimate how much strain chondrocytes embedded in the alginate bioink phase will experience under an applied stress of 0.03 MPa.

          (c)
You are tasked with designing composite 3D printed alginate/PCL
scaffolds for a tissue engineering application (Fig Q1c). The compressive
moduli of the alginate hydrogel and PCL polymer are 50 kPa and 60 MPa,
respectively.
i. Estimate how much alginate and PCL should be included in the
scaffold (in relative terms) to match native compressive modulus
of articular cartilage (2 MPa). State all assumptions you make for
your estimation.
ii. Based on your scaffold design, estimate how much strain
chondrocytes embedded in the alginate bioink phase will
experience under an applied stress of 0.03 MPa.

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c you are tasked with designing composite 3d printed alginatepcl scaffolds for a tissue engineering application fig q1c the compressive moduli of the alginate hydrogel and pcl polymer are 50 21105

Added by Brandon J.

University Physics with Modern Physics

Hugh D. Young 14th Edition

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Solved by Expert Adi S

11/18/2023

Step 1

We are given that $E_{alg} = 50 \, kPa = 0.05 \, MPa$, $E_{PCL} = 60 \, MPa$, and $E_{cart} = 2 \, MPa$. Let $x$ be the fraction of alginate and $1-x$ be the fraction of PCL in the scaffold. We assume that the composite modulus $E_{comp}$ is a linear combination Show more…

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(c) You are tasked with designing composite 3D printed alginate/PCL scaffolds for a tissue engineering application (Fig Q1c). The compressive moduli of the alginate hydrogel and PCL polymer are 50 kPa and 60 MPa, respectively. i. Estimate how much alginate and PCL should be included in the scaffold (in relative terms) to match native compressive modulus of articular cartilage (2 MPa). State all assumptions you make for your estimation. ii. Based on your scaffold design, estimate how much strain chondrocytes embedded in the alginate bioink phase will experience under an applied stress of 0.03 MPa.

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