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CASE STUDY C-5 A 40-year-old woman with abdominal pain, nausea, vomiting and jaundice is seen in the clinic. Laboratory tests are ordered on blood and urine. The following laboratory results are reported: Hemoglobin: Normal White blood cell count: Normal Serum Bilirubin Total: 6.5 mg/dL Conjugated (direct): 5.0 mg/dL Serum Enzymes Alanine transaminase (ALT): 300 U/L (normal: 0-45 U/L) Alkaline phosphatase (ALP): 180 U/L (normal: 0-150 U/L) Urine Appearance: Dark brown Urobilinogen: Normal/decreased Bilirubin: Positive Critical Thinking Questions 1. Discuss the possible etiologies of jaundice in this patient. 2. Where in the bilirubin pathway is the system overloaded or altered?

          CASE STUDY C-5
A 40-year-old woman with abdominal pain, nausea, vomiting and jaundice is seen in the clinic. Laboratory tests are ordered on blood and urine. The following laboratory results are reported:
Hemoglobin: Normal
White blood cell count: Normal
Serum Bilirubin
Total: 6.5 mg/dL
Conjugated (direct): 5.0 mg/dL
Serum Enzymes
Alanine transaminase (ALT): 300 U/L (normal: 0-45 U/L)
Alkaline phosphatase (ALP): 180 U/L (normal: 0-150 U/L)
Urine
Appearance: Dark brown
Urobilinogen: Normal/decreased
Bilirubin: Positive
Critical Thinking Questions
1. Discuss the possible etiologies of jaundice in this patient.
2. Where in the bilirubin pathway is the system overloaded or altered?

CASE STUDY C-5
A 40-year-old woman with abdominal pain, nausea, vomiting and jaundice is seen in the clinic. Laboratory tests are ordered on blood and urine. The following laboratory results are reported:
Hemoglobin: Normal
White blood cell count: Normal
Serum Bilirubin
Total: 6.5 mg/dL
Conjugated (direct): 5.0 mg/dL
Serum Enzymes
Alanine transaminase (ALT): 300 U/L (normal: 0-45 U/L)
Alkaline phosphatase (ALP): 180 U/L (normal: 0-150 U/L)
Urine
Appearance: Dark brown
Urobilinogen: Normal/decreased
Bilirubin: Positive
Critical Thinking Questions
1. Discuss the possible etiologies of jaundice in this patient.
2. Where in the bilirubin pathway is the system overloaded or altered?

Added by Jacob B.

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