Chapter 4: Explaining the Relationships between Energy (i.e. Free Energy), Activation Energy, and Endergonic and Exergonic Reactions. Which Types of Reactions are Spontaneous? Describing What Happens in Oxidation, Reduction, Dehydration Synthesis, and Hydrolysis Reactions. Explaining What Enzymes are and How They Facilitate Biological Reactions. How do the Terms Isozyme, Coenzyme, and Cofactor Apply to Enzymes? Defining Metabolism, Anabolism, and Catabolism. Listing the Ways Cells Control the Flow of Molecules through Metabolic Pathways. Nucleotide Coenzymes and Storage: ADP/ATP, NADH; FADH2, NADPH.