1. Acetone cannot be used as a solvent because the Grignard reagent will react with its carbonyl, instead of reacting with the planned synthesis carbonyl.
2. Tetrahydrofuran is not a suitable solvent for the Grignard reaction because its oxygen may form complexes with the Mg, deactivating the Grignard.
3. Phenol can be used as a solvent in the Grignard reaction as long as it is anhydrous and moisture is kept out of the system with a drying tube with drierite.
4. Syringes are used in the Grignard experiment to avoid mixing all the reagents. TRUE
5. We use syringes to inject the reagents through a septum, preventing moisture from entering the system.