Question

Cimetidine has a total clearance of 7.5 ml/min/kg, a volume of distribution of 1.2 L/kg and a fraction excreted unchanged of 0.6 in patients with normal kidney and liver functions. The regular oral dosage is 400 mg twice daily. The oral bioavailability of cimetidine is 70%. a) Calculate the renal, hepatic and total clearance in a 70‐ kg patient with normal hepatic but impaired renal function. The renal function is only 25%. b) The C ave (in mg/L) in this patient if given the regular dose. c) A new dose that will produce the same C ave as in the

          Cimetidine has a total clearance of 7.5 ml/min/kg, a volume of
distribution of 1.2 L/kg and a fraction excreted unchanged of 0.6
in patients with normal kidney and liver functions. The regular
oral dosage is 400 mg twice daily. The oral bioavailability of
cimetidine is 70%.
a) Calculate the renal, hepatic and total clearance in a 70‐
kg patient with normal hepatic but impaired renal
function. The renal function is only 25%.
b) The C ave (in mg/L) in this patient if given the regular
dose.
c) A new dose that will produce the same C ave as in the

Added by Patrick M.

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