00:01
Okay, this question here says, a 20 -year -old female presents to the dermatologist with complaints of multiple small to large 2mm to 3cm soft asymptomatic yellow color modular lesions all over the body since the age of 2 years.
00:20
She was subsequently referred to a biochemical investigation where an altered lipid profile was noticed.
00:25
A detailed history from the parents revealed that the patient developed a swelling since the age of 2 years, which gradually increased to the present size.
00:33
At the age of 3 years, the patient was treated by a local doctor, but the symptoms didn't subside.
00:39
There is no history of chest pain, breathlessness, hypertension, diabetes mellitus, or any other chronic illness.
00:46
Family history, maternal side shows history of sudden death at age 36 to 44.
00:51
So this is very important.
00:52
Sudden death in family at young age.
01:03
Okay, it says mothers, elder brother, and all his three sons have died at an early age due to possible myocardial infarction.
01:13
And it says lipid profile of the patient has a total cholesterol.
01:16
Total cholesterol here is increased.
01:20
Triglycerides are, well, they are not too high.
01:23
Then you have, oh, sorry, in this case, triglycerides are 134.
01:28
Then the ldl is 460, so it is increased.
01:32
The hdl is, it is practically normal, okay? the vldl is 27 in this case.
01:41
And the ldl -hdl ratio is 4 .94.
01:45
It says please describe the potential underlying mechanism for the elevated plasma cholesterol levels found in this individual...