00:01
Hello students, if a snp i .e.
00:04
Single nucleotide polymorphism is found to be associated with a particular condition, it does not necessarily mean that the snp directly causes the condition.
00:16
Snp association indicates the statistical correlation between the presence of a particular snp variant and the occurrence of a specific condition.
00:27
However, establishing a casual relationship requires further investigation.
00:33
The underlying mechanism of the association between snp and a condition can vary.
00:41
Alternatively, the snp might be directly involved in altering genes function or expression leading to the condition.
00:57
Alternatively, the associated snp could be a linkage disequilibrium with another nearby genetic variant that is casually related to the condition.
01:09
Then the association might be influenced by complex interaction between the multiple genetic and environmental factors.
01:19
To establish casuality, additional functional studies, experimental validations, and replication in independent populations is necessary and investigations aimed to determine how the snp variant or its linked variant contribute to the development or progression of the condition...