00:02
Okay, so we have the following substrate.
00:20
Okay, and we've got the nucleophile.
00:24
Oh, i think i see your problem.
00:28
You look like you've attached o -h -3, which is not the nucleophile.
00:33
You need o -c -h -3.
00:36
In either case, let's finish this out in case there was some other mistake.
00:45
The nucleophile will attack here and displace bromine.
00:50
And then the important thing is to just make sure we get the stereochemistry correct, right? so i think the easiest way for me to do this is just determine the stereochemistry of the substrate, right? so bromine is the highest priority followed by ch3, followed by deuterium, followed by the proton.
01:08
And then go figure out that it's clockwise or counterclockwise.
01:12
This is counterclockwise.
01:16
And because the lowest priority substituent is not in the back, counterclockwise corresponds to r.
01:22
So we started with an r stereoconfiguration.
01:27
So we will take our, which basically means if we're replacing priorities, you know, bromine will replace by oxygen, which has the same priority.
01:36
It'll be the highest priority that we want our product to have an s designation, right? so i'm going to include the o -c -h -3 and the methyl, and then what will be left is determining, you know, whether we want a wedge to deuterium or a wedge to hydrogen, right? so one way you can do that is just draw it, like, i'm going to draw it a wedge to deuterium.
02:05
And if that's wrong, i'll switch the two, right? so i'm going to put deuterium here and dash to hydrogen.
02:10
Okay.
02:12
And in fact, i know this will be correct, but for another reason.
02:17
But either way, you can say, okay, so now oxygen is number one, carbon is number two, deuterium is number three...