Question

Enols & Enolates 1. Predict the products from the two different reactions of the starting enone with two difference organometallic reagents below. Assume aqeous workup. MeLi Me2CuLi enone 2. In acidic deuterated water, D3O+, hydrogens are exchanged for deuterium via the keto-enol equilibrium. Provide the fully deuterated products of the reactions below. D3O+ D3O+ 3a. Two carbonyl compounds each with 5 carbons will produce the aldol product below. Determine the structure of the starting materials. LDA OH 3b. Deprotonation with strong base lithium diisopropylamide (LDA) at low temperatures followed by addition of 3-bromo-1-pentene yields the ketone shown on the right. Predict the starting material. LDA then, Br 4. Develop a reasonable, arrow-pushing reaction mechanim that explains the formation of the aldol condensation product below. + aq NaOH heat

          Enols & Enolates
1. Predict the products from the two different reactions of the starting enone with two difference organometallic reagents below. Assume aqeous workup.
MeLi
Me2CuLi
enone
2. In acidic deuterated water, D3O+, hydrogens are exchanged for deuterium via the keto-enol equilibrium. Provide the fully deuterated products of the reactions below.
D3O+
D3O+
3a. Two carbonyl compounds each with 5 carbons will produce the aldol product below. Determine the structure of the starting materials.
LDA
OH
3b. Deprotonation with strong base lithium diisopropylamide (LDA) at low temperatures followed by addition of 3-bromo-1-pentene yields the ketone shown on the right. Predict the starting material.
LDA
then, Br
4. Develop a reasonable, arrow-pushing reaction mechanim that explains the formation of the aldol condensation product below.
+
aq NaOH
heat

Enols Enolates
1. Predict the products from the two different reactions of the starting enone with two difference organometallic reagents below. Assume aqeous workup.
MeLi
Me2CuLi
enone
2. In acidic deuterated water, D3O+, hydrogens are exchanged for deuterium via the keto-enol equilibrium. Provide the fully deuterated products of the reactions below.
D3O+
D3O+
3a. Two carbonyl compounds each with 5 carbons will produce the aldol product below. Determine the structure of the starting materials.
LDA
OH
3b. Deprotonation with strong base lithium diisopropylamide (LDA) at low temperatures followed by addition of 3-bromo-1-pentene yields the ketone shown on the right. Predict the starting material.
LDA
then, Br
4. Develop a reasonable, arrow-pushing reaction mechanim that explains the formation of the aldol condensation product below.
+
aq NaOH
heat

Added by Elizabeth W.

Question

Please give Ace some feedback