00:01
The astirification reaction is one of the mainstays of organic synthesis.
00:14
Sometimes this is called a fissure esterification.
00:19
And in the reaction, a generalized carboxylic acid reacts with methanol to give the ester plus water in a balanced equation.
00:46
The issue at hand for this problem is to suggest the result based on the mechanism of using radioactive methanol, namely, does the radio label wind up in the water, or does it wind up with the ester? this is actually a very crucial experiment in defining the mechanism of this particular reaction and is sort of a classic result.
01:13
It should be noted that this reaction is typically acid -catalyzed, takes a little acid to get the thing to go well.
01:21
It is also, in theory, reversible.
01:24
In the reverse direction, this is called an esterhyproglysis.
01:28
But if you run a reaction in methodology, it essentially goes to completion.
01:34
The best way to understand this mechanism is to draw these molecules with their lone pairs a little better defined...