HO H OH + CH$_3$-C-OH + H$_3$C CH$_3$ Acetic acid OH Acetic anhydride Salicylic acid O-C-CH$_3$ Acetylsalicylic acid
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The acid catalyst (H+) protonates one of the carbonyl oxygens of acetic anhydride ((CH3CO)2O), increasing the electrophilicity of the adjacent carbonyl carbon and activating the anhydride toward nucleophilic attack. Show more…
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