Lactate dehydrogenase (LDH) has a quaternary structure composed of a total of (how many?) subunits. In vertebrates, the monomer comes in at least two , which catalyze the same reaction and have very similar (but not identical) sequences. When these monomers come together in different combinations to form the full quaternary structure, these different combinations are called
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Lactate dehydrogenase (LDH) has a quaternary structure composed of a total of 4 subunits. Show more…
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Lactate dehydrogenase is one of the many enzymes that require NADH as coenzyme. It catalyzes the conversion of pyruvate to lactate: (FIGURE CAN'T COPY) Draw the mechanism of this reaction (show electron-pushing arrows). (Hint: This is a common reaction throughout metabolism; the mechanism is similar to that catalyzed by other dehydrogenases that use NADH, such as alcohol dehydrogenase.)
The enzyme lactate dehydrogenase catalyzes the reaction shown below. Incubation of 4R-2H-NADH with enzyme and pyruvate gives no incorporation of deuterium in the lactate product. However, incubation of 4S-2H-NADH with enzyme and pyruvate gives 2S-2H-lactate. Write a mechanism for this reaction to explain these results.
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