Question

Meningococcal disease, caused by the bacterium Neisseria meningitidis, is a severe, life-threatening illness with rapid onset and progression of symptoms. Case-fatality rates can be as high as 10%–20% among people who receive treatment (likely higher if not treated). Approximately 11%–19% of survivors have major long-term consequences, including loss of limbs, deafness, and seizures. In the United States, meningococcal disease incidence has steadily declined since 1995 (1.20 cases/100,000 persons) to a historic low of 0.11 cases/100,000 persons in 2017. We reviewed university-based outbreaks of meningococcal disease caused by serogroup B and vaccination responses in the United States in the years following serogroup B meningococcal (MenB) vaccine availability. Ten university-based outbreaks occurred in 7 states during 2013–2018, causing a total of 39 cases and 2 deaths. Outbreaks occurred at universities with 3,600–35,000 undergraduates. Outbreak case counts ranged from 2 to 9 cases; outbreak duration ranged from 0 to 376 days. All 10 universities implemented MenB vaccination: 3 primarily used MenB-FHbp and 7 used MenB-4C. Estimated first-dose vaccination coverage ranged from 14% to 98%. University Location | Outbreak time period | Case Counts (Number of cases) | Death Counts (Number of deaths) | Number of undergrad students | % of students who received first dose vaccine --- | --- | --- | --- | --- | --- New Jersey | Mar 2013 – Mar 2014 | 9 | 1 | 5,000 | 95% California | Nov 2013 | 4 | 0 | 19,000 | 51% Rhode Island | Jan – Feb 2015 | 2 | 0 | 3,700 | 94% Oregon A | Jan – May 2015 | 7 | 1 | 20,000 | 52% California | Jan – Feb 2016 | 2 | 0 | 5,000 | 90% New Jersey | Mar – Apr 2016 | 2 | 0 | 35,000 | NA Wisconsin | Oct 2016 | 3 | 0 | 30,000 | 67% Oregon B | Nov 2016 – Nov 2017 | 5 | 0 | 25,000 | 98% Massachusetts | Oct 2017 – Feb 2018 | 3 | 0 | 26,000 | 34% Pennsylvania | Nov 2017 | 2 | 0 | 3,600 | 14% Question What is the risk of meningococcal B disease at university Oregon B? That is, what's the risk of being a case among university Oregon B students in the time period observed?

          Meningococcal disease, caused by the bacterium Neisseria meningitidis, is a severe, life-threatening illness with rapid onset and progression of symptoms. Case-fatality rates can be as high as 10%–20% among people who receive treatment (likely higher if not treated). Approximately 11%–19% of survivors have major long-term consequences, including loss of limbs, deafness, and seizures. In the United States, meningococcal disease incidence has steadily declined since 1995 (1.20 cases/100,000 persons) to a historic low of 0.11 cases/100,000 persons in 2017.

We reviewed university-based outbreaks of meningococcal disease caused by serogroup B and vaccination responses in the United States in the years following serogroup B meningococcal (MenB) vaccine availability. Ten university-based outbreaks occurred in 7 states during 2013–2018, causing a total of 39 cases and 2 deaths. Outbreaks occurred at universities with 3,600–35,000 undergraduates. Outbreak case counts ranged from 2 to 9 cases; outbreak duration ranged from 0 to 376 days. All 10 universities implemented MenB vaccination: 3 primarily used MenB-FHbp and 7 used MenB-4C. Estimated first-dose vaccination coverage ranged from 14% to 98%.

University Location | Outbreak time period | Case Counts (Number of cases) | Death Counts (Number of deaths) | Number of undergrad students | % of students who received first dose vaccine
--- | --- | --- | --- | --- | ---
New Jersey | Mar 2013 – Mar 2014 | 9 | 1 | 5,000 | 95%
California | Nov 2013 | 4 | 0 | 19,000 | 51%
Rhode Island | Jan – Feb 2015 | 2 | 0 | 3,700 | 94%
Oregon A | Jan – May 2015 | 7 | 1 | 20,000 | 52%
California | Jan – Feb 2016 | 2 | 0 | 5,000 | 90%
New Jersey | Mar – Apr 2016 | 2 | 0 | 35,000 | NA
Wisconsin | Oct 2016 | 3 | 0 | 30,000 | 67%
Oregon B | Nov 2016 – Nov 2017 | 5 | 0 | 25,000 | 98%
Massachusetts | Oct 2017 – Feb 2018 | 3 | 0 | 26,000 | 34%
Pennsylvania | Nov 2017 | 2 | 0 | 3,600 | 14%

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What is the risk of meningococcal B disease at university Oregon B? That is, what's the risk of being a case among university Oregon B students in the time period observed?

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