Table 2: Typical pKa values of ionizable groups in proteins
Group Acid Base
Typical pKa *
Terminal carbonyl group
Aspartic acid Glutamic acid
Histidine
Terminal amino group
Cysteine
Tyrosine
10.9
Lysine
10.8
Arginine
12.5
pKa value: depends on temperature, ionic strength, and the microenvironment of the ionizable group.