Question

1. Amoxicillin is a broad spectrum antibiotic. It is usually given orally. It is a triprotic acid with pKa of 2.67, 7.11, and 9.55. H2N-H pKa = 9.55 HO S pKa = 7.11 amoxicillin OH pKa = 2.67 a. When amoxicillin enters your stomach (pH 3), what is the charge? Give the charge of the compound present in the highest amount. b. As amoxicillin passes into the intestines (pH 6), what is the charge? Give the charge of the compound present in the highest amount. c. When amoxicillin enters the blood (pH 7.4), what is the charge? Give the charge of the compound present in the highest amount.

          1. Amoxicillin is a broad spectrum antibiotic. It is usually given orally. It is a triprotic acid with pKa of 2.67, 7.11, and 9.55.
H2N-H pKa = 9.55
HO
S
pKa = 7.11
amoxicillin
OH
pKa = 2.67
a. When amoxicillin enters your stomach (pH 3), what is the charge? Give the charge of the compound present in the
highest amount.
b. As amoxicillin passes into the intestines (pH 6), what is the charge? Give the charge of the compound present in the
highest amount.
c. When amoxicillin enters the blood (pH 7.4), what is the charge? Give the charge of the compound present in the
highest amount.

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1. Amoxicillin is a broad spectrum antibiotic. It is usually given orally. It is a triprotic acid with pKa of 2.67, 7.11, and 9.55.
H2N-H pKa = 9.55
HO
S
pKa = 7.11
amoxicillin
OH
pKa = 2.67
a. When amoxicillin enters your stomach (pH 3), what is the charge? Give the charge of the compound present in the
highest amount.
b. As amoxicillin passes into the intestines (pH 6), what is the charge? Give the charge of the compound present in the
highest amount.
c. When amoxicillin enters the blood (pH 7.4), what is the charge? Give the charge of the compound present in the
highest amount.

Added by Sarah G.

Chemistry: Structure and Properties

Nivaldo Tro 2nd Edition

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Solved by Expert Tracy Tourville

Step 1

When amoxicillin enters your stomach (pH 3), the pH is lower than the pKa values of all three ionizable groups in amoxicillin. This means that all three groups will be protonated (charged) in the stomach. The compound present in the highest amount will be the one Show more…

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Please type write the answer with all the steps. I have been posting questions that I need help on, and some "Chegg experts" write it so terribly that I don't understand it and lose my question that I paid for. I WILL LEAVE A LIKE IF IT'S CORRECT AND READABLE, IF NOT, I WILL LEAVE A DISLIKE! 1. Amoxicillin is a broad-spectrum antibiotic. It is usually given orally. It is a triprotic acid with pKa values of 2.67, 7.11, and 9.55. pKa = 9.55 HaN pKa = 7.11 OH Amoxicillin pKa = 2.67 a. When amoxicillin enters your stomach (pH 3), what is the charge? Give the charge of the compound present in the highest amount. b. As amoxicillin passes into the intestines (pH 6), what is the charge? Give the charge of the compound present in the highest amount. c. When amoxicillin enters the blood (pH 7.4), what is the charge? Give the charge of the compound present in the highest amount.

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