Problem 3 – 10 points The following results were obtained in an occupational cohort study of the risk of cancer associated with exposure to radiation. Radiation dose (rem) | Total population (baseline) | Cancer cases 0-0.99 | 3642 | 390 1.00-4.99 | 1504 | 181 5+ | 1320 | 222 Calculate the rate of disease in each radiation dose level. Calculate the relative risks using the lowest radiation category as the reference category. Interpret your findings.
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For the 0-0.99 rem category: Rate = (Cancer cases / Total population) = (390 / 3642) = 0.1071 For the 1.00-4.99 rem category: Rate = (Cancer cases / Total population) = (1320 / 1504) = 0.8777 For the 5.00+ rem category: Rate = (Cancer cases / Total population) Show more…
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The following results were obtained in an occupational cohort study of the risk of cancer associated with exposure to radiation (assume no loss to follow-up): Fill in the empty cells in the table. For calculations of relative risks and odds ratios, use the lowest radiation category as the reference group (this means the RR or OR will be a numeric value that represents no effect): Radiation Dose (rem) Total Population Cumulative Incidence Cases Odds Ratio (comparing cases to non-cases) Relative Risk (comparing cases to total population) 0-0.99 3642 390 1-4.99 1504 181 5+ 1320 222
Madhur L.
At the end of 2010, 58 new cases of acute lymphocytic leukemia (ALL) were reported among the 2,480 inhabitants of Santa Claus, Indiana. In the next year, a cohort study was conducted among 450 participants who were followed for 5 years. Of these participants, 144 had exposure to radiations at baseline of whom 21 developed ALL during the study period. Only 6 of the participants who did not have exposure to radiations at baseline developed ALL by the end of the study. Assuming that none of the participants were lost to follow up, calculate the population attributable fraction (population attributable risk percent) for radiations on the incidence of ALL (show how you arrived at your final answer) (10 points).
Supreeta N.
A doctor claims that less than 30 percent of all persons exposed to a certain amount of radiation will feel any ill effects. If, in a random sample, only 1 of 19 persons exposed to such radiation felt any ill effects, test the null hypothesis $\theta=0.30$ against the alternative hypothesis $\theta<0.30$ at the $0.05$ level of significance.
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