00:01
Ok this question says, a 12 year old boy underwent the tooth extraction and experienced persistent bleeding following the procedure.
00:07
The patient has a history of bruising and frequent epistatics.
00:10
The patient's mother also experienced easy bruising and menorrhagia.
00:15
A physical examination reveals several echemotic lesions on the lower extremities and laboratory findings are described below.
00:22
You have that the pt is normal, the protuberant time is normal.
00:30
Then you have the activated pt is going to be prolonged in this case.
00:38
Then you have that the bleeding time is also prolonged.
00:48
Then you have the factor 8 activity is decreased.
01:01
Then you have the bone willebram factor anti -aging is decreased.
01:15
And you have here the bone willebram factor glistosidine cofactor.
01:23
Glistosidine cofactor is also decreased.
01:33
And finally you have the glistosidine, that stands for glistosidine induced platelet aggregation, is going to be, well it has a depressed response.
01:48
Okay, so this is what you have.
01:50
So the question is asking, what disorder is present? so according to all of this information, the most likely answer in this case is going to be bone willebram disease.
02:13
Bone willebram disease is a genetic bleeding disorder caused by a deficiency or dysfunction of bone willebram factor, a protein that plays an important role in platelet adhesion and also aggregation.
02:27
The decreased levels of bone willebram factor result in impaired platelet function and abnormal population.
02:34
The inheritance pattern of this condition is usually autosomal dominant.
02:39
And well, in this case, the patient's family history of ecv -seeing and menogaia is also suggestible of this condition.
02:45
Remember that this condition presents with a not severe bleeding.
02:50
Okay, the condition is relatively benign.
02:53
In this case, this level here is usually normal.
02:56
This level here is usually also normal, but depending on the severity, it can be prolonged.
03:01
In this case, the platelet number also, if you do a blood smear or a complete blood count, you're going to see that the platelet levels are normal, but the bleeding time is going to be increased...