Q2) Ester-type of prodrugs are bioactivated in the body by oxidation A. True B. False
Added by Stacey A.
Close
Step 1
Hydrolysis breaks the ester bond, releasing the active drug. While some ester prodrugs might undergo oxidation as a secondary metabolic pathway, it's not the primary mechanism of bioactivation. Show more…
Show all steps
Your feedback will help us improve your experience
Dinesh Singh and 82 other Chemistry 101 educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Which of the following terms best describes the process required to make a prodrug active or more active? a. Detoxification b. Biotransformation c. Dissolution d. Digestion 2. Conversion of Epinephrine to Epinephrine hydrochloride involves which physicochemical property? a. Extent of ionization b. Chirality c. Polymorphism d. Salt formation 3. Napsylate, besylate, citrate, and palmitate are examples of which of the following? a. Solvates b. Metastable polymorphs c. Prodrugs d. Salts 4. Which of the following prodrugs is a dimer of its active metabolite? a. Menadione b. Olsalazine c. Chloramphenicol d. Enalapril 5. Which of the following conditions will increase the rate of drug dissolution from a tablet? a. Utilization of ionized form of the drug b. Utilization of free acid or free base form of the drug 6. Which of the following is the most accurate description of organic compounds? a. Strong electrolytes b. Have high ionization constants c. Highly ionizable compounds d. Weak electrolytes
Dinesh S.
A drug contains an ionized carboxylate group and shows good activity against its target in in vitro tests. When in vivo tests were carried out, the drug showed poor activity when it was administered orally, but good activity when it was administered by intravenous injection. The same drug was converted to an ester, but proved inactive in vitro. Despite that, it proved to be active in vivo when it was administered orally. Explain these observations.
Sri K.
Weakly acidic drugs dissociate into negatively charged ions and are then less lipophilic True False
Dave K.
Recommended Textbooks
Chemistry: Structure and Properties
Chemistry The Central Science
Chemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD