Once pyridoxamine phosphate (PMP) is formed, it can be used to facilitate a transamination process for the conversion of alpha-ketoglutarate to glutamate (ketone to amine). This process is important because it is used in the synthesis of the amino acid glutamine and in the metabolism of glucose. In the first step, alpha-ketoglutarate condenses with PMP to give an iminium ion intermediate. Predict the structure of this iminium ion intermediate:
Added by Johnathan G.
Close
Step 1
Represent alpha‑ketoglutarate as HOOC–CH2–CH2–C(=O)–COOH and pyridoxamine‑5′‑phosphate (PMP) by its reactive aminomethyl group attached to the pyridine ring, abbreviated as PMP–CH2–NH2. Show more…
Show all steps
Your feedback will help us improve your experience
Ripujeet P and 96 other Chemistry 101 educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Write all the steps in the transamination reaction of PMP with $\alpha$ -ketoglutarate plus a lysine residue in the enzyme to give the PLP-enzyme imine plus glutamate.
N-Acetylglutamate is required as a cofactor in the synthesis of carbamoyl phosphate. How is $N$ acetylglutamate synthesized from glutamate?
Aprobarbital, a barbiturate once used in treating insomnia, is synthesized in three steps from diethyl malonate. Show how you would synthesize the necessary dialkylated intermediate, and then propose a mechanism for the reaction of that intermediate with urea to give aprobarbital. (FIGURE CAN'T COPY)
Recommended Textbooks
Chemistry: Structure and Properties
Chemistry The Central Science
Chemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD
