Given the (rounded) pKa values for the amino acid histidine, estimate its net charge under the following conditions: Histidine has three ionizable protons with pKa values of 2, 6, and 9. pH 0 pH 2 pH 4 pH 6 pH 9 pH 11 [ Choose ] -1.5 +1.5 0 -0.5 -2 -1 +2 +0.5 +1
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Histidine has three ionizable groups: the amino group (pK1 = 2), the carboxyl group (pK2 = 9), and the imidazole side chain (pK3 = 6). At pH 0, all these groups will be protonated, so the net charge will be +2 for the amino group, 0 for the carboxyl group, and +1 Show more…
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