Esters and amides are most easily made by nucleophilic acyl substitution reactions on: Select one: a. alcohols b. acid anhydrides c. carboxylates d. carboxylic acids e. acid chlorides
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Acid chlorides have a chlorine atom attached to the carbonyl carbon, which pulls electron density towards itself, making the carbon more electrophilic and reactive. Show more…
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a. Rank the following esters from most reactive to least reactive in the first slow step of a nucleophilic acyl substitution reaction (formation of the tetrahedral intermediate): A B C D b. Rank the same esters from most reactive to least reactive in the second slow step of a nucleophilic acyl substitution reaction (collapse of the tetrahedral intermediate).
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