1. Sample of 1 mL were collected at predefined time point from 900 mL vessels filled with dissolution media in order to obtain the dissolution profile of 500 mg paracetamol tablet using paddle apparatus. Each sample was diluted to 30 mL with dissolution media and absorbance was read using UV spectrophotometer. Calculate the %amount of dissolved paracetamol if the average of 3 consequtive measurements is 0.928. The calibration curve for paracetamol is y=0,061x + 0,093 where: x is concentration in ?g/mL; y absorbance.
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First, we need to find the concentration (x) of paracetamol in the diluted sample using the calibration curve equation: y = 0.061x + 0.093. Show more…
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