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Alterations in activity at dopamine synapses are implicated in the development of anxiety, schizophrenia, alzheimer's or nicotine addiction.
00:11
So the answer to this one is schizophrenia, and this is called the dopamine hypothesis.
00:17
So the dopamine hypothesis of schizophrenia is that it's an alteration in dopamine receptors that cause both positive and negative symptoms.
00:27
So it's hyperactivity of dopamine d2 receptors and hypoactivity of d1 receptors.
00:38
So this hyperactivity of d2 causes the positive symptoms, so hallucinations and delusions.
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The hypoactivity of d1 causes the negative symptoms, the poverty of speech, the lack of movement, the lack of effect, etc.
00:54
And you can see some evidence in this in looking at how antipsychotics work...