'Suppose Fe want to detect & difference in Inean between tWO cholesterol values of 12 units treatments (new treatment and old treatment) with 95% power'
Added by James E.
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First, we need to determine the sample size required to detect a difference of 12 units in the mean cholesterol values between the two treatments with 95% power. Show more…
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The following data were collected in a clinical trial to compare a new drug to a placebo for its effectiveness in lowering total serum cholesterol. New Drug (n=75) Placebo (n=75) Total Sample (n=150) Mean (SD) Total Serum Cholesterol 182.0 (24.5) 206.3 (21.8) 194.15 (23.2) % Patients with Total Cholesterol < 200 78.0% 65.0% 71.5% 1. Generate the 95% confidence interval for the difference in mean total cholesterol levels between treatments 2. Generate a 95% confidence interval for the difference in proportions of all patients with total cholesterol < 200.
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Suppose we want to design a new placebo-controlled trial to evaluate an experimental medication to decrease total cholesterol. The primary outcome is total cholesterol, a continuous variable measured in mg/dL. The primary outcome will be measured after six months of treatment. How many subjects should be enrolled to ensure 80% power (tβ = 0.84) to detect a difference of 8 mg/dL with a two-sided test and α = 0.05? The investigators expect to lose 10% of the participants over the course of follow-up. Assume that the standard deviation of total cholesterol is 16.5.
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