The drug of choice for the treatment of acute symptomatic gout is
Added by Tony J.
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Step 1: Indomethacin (an NSAID) is the drug of choice for acute symptomatic gout. Show more…
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Gout patients have high uric acid levels in their blood and suffer from arthritis in their joints as a result of formation of intracellular and extracellular uric acid crystals. Would you expect treatment with glucocorticoids, which inhibit prostaglandin synthesis, or with tumor necrosis factor to be normally used to treat such patients? Why?
Lainey R.
Treatment of Gout Allopurinol (see Fig. $22-50$ ), an inhibitor of xanthine oxidase, is used to treat chronic gout. Explain the biochemical basis for this treatment. Patients treated with allopurinol sometimes develop xanthine stones in the kidneys, although the incidence of kidney damage is much lower than in untreated gout. Explain this observation in the light of the following solubilities in urine: uric acid, 0.15 $\mathrm{g} / \mathrm{L} ;$ xanthine, $0.05 \mathrm{g} / \mathrm{L} ;$ and hypoxanthine, $1.4 \mathrm{g} / \mathrm{L}$
What is the biochemical basis of allopurinol treatment for gout?
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