The duration of action of a barbiturate will depend most on: intensity of action active metabolism speed of absorption
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Step 1: The duration of action of a barbiturate is determined by how quickly it is metabolized and eliminated from the body. Show more…
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When administering a new medication to a patient, the nurse reads that it is highly protein bound. Assuming that the patient‘s albumin levels are normal, the nurse would expect which result, as compared to a medication, that is not highly protein bound? a. Renal excretion will be faster. b. The drug will be metabolized quickly. c. The duration of action of the medication will be shorter. d. The duration of action of the medication will be longer.
Breanna O.
ASSIGNMENTS 1. Write briefly on five(5) factors affecting biotransformation of drugs. 2. Briefly describe the mechanisms by which drugs (and nutrients) can influence each other during absorption, distribution, metabolism and excretion. Give 3 examples of these interactions. 3. Describe how Paracetamol is metabolized with emphases on the impact of liver enzyme inducers and inhibitors. 4. Epilepsy is often treated with a combination of drugs such as carbamazepine and phenytoin (polytherapy). CYP3A4 is induced by phenytoin and carbamazepine. Carbamzeipine by not phenytoin is cleared by CYP3A4. What problems might you expect if (a) carbamazepine is removed or (b) phenytoin is removed from this two-drug regimen.
Adi S.
Pharmacokinetics is the study of the rates of absorption and elimination of drugs by organisms. In most cases, elimination is slower than absorption and is a more important determinant of availability of a drug for binding to its target. A drug can be eliminated by many mechanisms, such as metabolism in the liver, intestine, or kidney followed by excretion of breakdown products through urine or feces. As an example of pharmacokinetic analysis, consider the elimination of beta adrenergic blocking agents (beta blockers), drugs used in the treatment of hypertension. After intravenous administration of a beta blocker, the blood plasma of a patient was analyzed for remaining drug and the data are shown below, where c is the drug concentration measured at a time t after the injection. t/min 30 60 120 150 240 360 480 c/(ng cm^-3) 699 622 413 292 152 60 24
Adriano C.
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