The $k_{\text {cat }}$ for alkaline phosphatase-catalyzed hydrolysis of methylphosphate is approximately $14 /$ sec at $\mathrm{pH} 8$ and $25^{\circ} \mathrm{C}$. The rate constant for the uncatalyzed hydrolysis of methylphosphate under the same conditions is approximately $10^{-15} /$ sec. What is the difference in the free energies of activation of these two reactions?
Added by Brian S.
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We are given the rate constants for the catalyzed and uncatalyzed reactions: $k_{cat} = 14 \, \text{s}^{-1}$ and $k_{uncat} = 10^{-15} \, \text{s}^{-1}$. Show more…
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