Question

5. The natural product monensin belongs to a family of compounds known as ionophores. These compounds can serve to complex with and transport cations, a property which often results in biological activity. Monensin is a compound used in the poultry business to treat coccidial infections, a serious problem in this multi-billion dollar industry. A total synthesis has been described by Kishi at Harvard. A portion of the synthesis is detailed below:

          5.
The natural product monensin belongs to a family of compounds known as ionophores.
These compounds can serve to complex with and transport cations, a property which
often results in biological activity. Monensin is a compound used in the poultry business
to treat coccidial infections, a serious problem in this multi-billion dollar industry. A
total synthesis has been described by Kishi at Harvard. A portion of the synthesis is
detailed below:

5.
The natural product monensin belongs to a family of compounds known as ionophores.
These compounds can serve to complex with and transport cations, a property which
often results in biological activity. Monensin is a compound used in the poultry business
to treat coccidial infections, a serious problem in this multi-billion dollar industry. A
total synthesis has been described by Kishi at Harvard. A portion of the synthesis is
detailed below:

Added by Jesse N.

Chemistry: Structure and Properties

Nivaldo Tro 2nd Edition

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The natural product monensin belongs to a family of compounds known as ionophores. These compounds can serve to complex with and transport cations, a property which often results in biological activity. Monensin is a compound used in the poultry business to treat coccidial infections, a serious problem in this multi-billion dollar industry. A total synthesis has been described by Kishi at Harvard. A portion of the synthesis is detailed below: OCOCH3 HO HOO (steps) H2C H2C OCH3 COH Monensin