Question

The partition coefficient of a basic alkaloid is KD = 3.0 and the acid dissociation constant of BH+ is Ka = 1.0  10−9 . (a) (b) (c) Determine the distribution coefficient (D) at pH 10 when 50 mL of dissolved alkaloid in water is extracted with 25 mL of toluene. After extraction of the aqueous amine solution with 25 mL of toluene, what fraction of alkaloid remains in the aqueous phase? What fraction of alkaloid remains in the aqueous phase after 3 extractions with 25 mL of portions of toluene?

          The partition coefficient of a basic alkaloid is KD = 3.0 and the acid dissociation constant of BH+
is Ka = 1.0  10−9
.
(a) (b) (c) Determine the distribution coefficient (D) at pH 10 when 50 mL of dissolved alkaloid in
water is extracted with 25 mL of toluene.
After extraction of the aqueous amine solution with 25 mL of toluene, what fraction of
alkaloid remains in the aqueous phase?
What fraction of alkaloid remains in the aqueous phase after 3 extractions with 25 mL
of portions of toluene?

Added by Diane P.

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