00:01
Of a eukaryotic chromosome near the peroneal region, which is always shown in the region.
00:08
So the eukaryotic organism, they have lenient chromosome.
00:16
So this is a problem at the end of the chromosome when it comes to replication.
00:22
So let me write down, draw the structure of, let's say this is the end of chromosome.
00:32
And now let's say the origin of replication is somewhere here.
00:40
So this is three and this is five.
00:43
And of course you have the rest of the strand.
00:48
So for the top strand, it's very easy to synthesize new dna strand because dna synthesize or dna replication goes from five to three direction naturally.
00:59
This is determined by the nature of the dna polymerase.
01:08
And so this is why for the top strand, the dna synthesis start from the origin of replication, five in the middle, which is opposite to the template.
01:18
And then go this way.
01:20
So this is done continuously.
01:24
This is called the leading strand.
01:27
Or i think in your case, it called direct strand.
01:32
But if you look at the bottom strand, there's a problem because the dna can only go from five to three.
01:38
So this means that the bottom strand cannot start from the origin of replication, which is three primate and go this way, which is five.
01:46
So this is not going to work out.
01:48
So instead you're gonna have to synthesize backwards.
01:58
So to solve this problem, for the bottom strand, you will have to have all akazaki fragment that is away from the origin of replication.
02:08
So the first akazaki fragment is gonna be five here, synthesized towards the replication, the origin of replication this way.
02:17
So this is called the first akazaki fragment.
02:27
And then the second one is gonna be to the left of the first piece, five towards three.
02:36
And the last one is five towards three.
02:39
So you can see we have three akazaki fragment right here.
02:42
So the first piece is here, the second and the third.
02:45
So we can see that they are being synthesized discontinuously and eventually all these different akazaki fragment will be synthesized or will be ligated together to become a continuous strand...