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The titration curve for Histidine is shown labeled at key points on the graph with the letters A-F. The following questions refer to this titration curve. Answer the following questions with the letter that signifies the correct position on the curve. Histidine Titration 12.0 10.0 8.0 6.0 4.0 2.0 0.0 0.0 0.5 1.0 1.5 2.0 2.5 3.0 pH Equivalents OH- A B C D E F Question 1 Point that represents pKa1? Question 2 Point that represents a 50/50 mixture of the plus 1 and 0 charged species? Question 3 Point at which the major molecular species has a net charge of 0? Question 4 Point at which all the carboxylic acid groups are completely deprotonated? Question 5 Point at which His shows no movement in an electrophoretic field? Question 6 Point that represents pKa2 i.e. the pKa of the alpha amino group? Question 7 Point at which the net charge on the major amino acid species is negative one? Question 8 Point at which the R group is half ionized? Question 9 Point that represents the isoelectric point of this amino acid? Question 10 Point at which are there as many molecules with a net charge of 0 as have a net charge of -1?

          The titration curve for Histidine is shown labeled at key points on the graph with the letters A-F.
The following questions refer to this titration curve. Answer the following questions with the letter that signifies the correct position on the curve.

Histidine Titration
12.0
10.0
8.0
6.0
4.0
2.0
0.0
0.0 0.5 1.0 1.5 2.0 2.5 3.0
pH
Equivalents OH-
A
B
C
D
E
F

Question 1 Point that represents pKa1?
Question 2 Point that represents a 50/50 mixture of the plus 1 and 0 charged species?
Question 3 Point at which the major molecular species has a net charge of 0?
Question 4 Point at which all the carboxylic acid groups are completely deprotonated?
Question 5 Point at which His shows no movement in an electrophoretic field?
Question 6 Point that represents pKa2 i.e. the pKa of the alpha amino group?
Question 7 Point at which the net charge on the major amino acid species is negative one?
Question 8 Point at which the R group is half ionized?
Question 9 Point that represents the isoelectric point of this amino acid?
Question 10 Point at which are there as many molecules with a net charge of 0 as have a net charge of -1?

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The titration curve for Histidine is shown labeled at key points on the graph with the letters A-F.
The following questions refer to this titration curve. Answer the following questions with the letter that signifies the correct position on the curve.

Histidine Titration
12.0
10.0
8.0
6.0
4.0
2.0
0.0
0.0 0.5 1.0 1.5 2.0 2.5 3.0
pH
Equivalents OH-
A
B
C
D
E
F

Question 1 Point that represents pKa1?
Question 2 Point that represents a 50/50 mixture of the plus 1 and 0 charged species?
Question 3 Point at which the major molecular species has a net charge of 0?
Question 4 Point at which all the carboxylic acid groups are completely deprotonated?
Question 5 Point at which His shows no movement in an electrophoretic field?
Question 6 Point that represents pKa2 i.e. the pKa of the alpha amino group?
Question 7 Point at which the net charge on the major amino acid species is negative one?
Question 8 Point at which the R group is half ionized?
Question 9 Point that represents the isoelectric point of this amino acid?
Question 10 Point at which are there as many molecules with a net charge of 0 as have a net charge of -1?

Added by Jason C.

Chemistry: Structure and Properties

Nivaldo Tro 2nd Edition

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Solved by Expert Dominador Tan

01/23/2023

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The titration curve for Histidine is shown labeled at key points on the graph with the letters A-F. The following questions refer to this titration curve. Answer the following questions with the letter that signifies the correct position on the curve. Histidine Titration Question 1: Point that represents pKa1? Question 2: Point that represents a 50/50 mixture of the plus 1 and 0 charged species? Question 3: Point at which the major molecular species has a net charge of 0? Question 4: Point at which all the carboxylic acid groups are completely deprotonated? Question 5: Point at which His shows no movement in an electrophoretic field? Question 6: Point that represents pKa2 i.e. the pKa of the alpha amino group? Question 7: Point at which the net charge on the major amino acid species is negative one? Question 8: Point at which the R group is half ionized? Question 9: Point that represents the isoelectric point of this amino acid? Question 10: Point at which are there as many molecules with a net charge of 0 as have a net charge of -1?

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00:01 One we have our pca so our pka is equal to 1 .81 your ph is equals to pka when the concentration of the concentration of from a part and the concentration form from b part will be equal your point a represent your pca second is we have the positive one this is the species is formed in point b and basically we have have our o, which this is the species which is formed in point c.

00:37 So ph is equals to pca plus log.

00:44 We have our salt and you need to divide it by the acid.

00:51 So we have pca plus log point c over point b.

01:01 And point c is equals to point b.

01:06 This would be equal to 50.

01:09 So our ph is equal to pca, our subscript is equal to 2, so we have equal to 6 .05.

01:18 So the point c just above ph is equal to 6.

01:22 It makes sense that the point c that represent ph is equal to 6 .05, having a 50 -50 mixture of species, which is the positive 1 and 0.

01:33 For number three, the major molecule is the zero charge species, and we have c is the major above.

01:45 So ph is equal to 6 .05.

01:48 When your ph is above 6 .05, then the major point will be species c.

01:54 And point d represent this one.

01:59 Actually, at ph is equal to pca is equal to 1 .81, so it means it's 50.

02:04 50 -50 mixture of forms a and b.

02:07 Then with increase in ph amount of your point b increases, now when your ph is equal to p -k -a, so the number form of your species a is present, but there is 50 -50 mixture of species b and species c.

02:24 So from point b and onwards.

02:27 So this would be from point b and onwards.

02:29 For question number four, here only one c ooh group is present...

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