Question

Thiamin diphosphate (TPP), a derivative of vitamin $B_{1}$ required for glucose metabolism, is a weak acid that can be deprotonated by base. Assign formal charges to the appropriate atoms in both TPP and its deprotonation product.

Name: Thiamin diphosphate (TPP), a derivative of vitamin B1 required for glucose metabolism, is a weak acid that can be deprotonated by base. Assign formal charges to the appropriate atoms in both TPP and its deprotonation product.
Uploaded: 2022-01-04T17:13:04-08:00
Duration: 2 min 14 s
Channel: Lottie Adams
Description: Thiamin diphosphate (TPP), a derivative of vitamin B1 required for glucose metabolism, is a weak acid that can be deprotonated by base. Assign formal charges to the appropriate atoms in both TPP and its deprotonation product.

          Thiamin diphosphate (TPP), a derivative of vitamin $B_{1}$ required for glucose metabolism, is a weak acid that can be deprotonated by base. Assign formal charges to the appropriate atoms in both TPP and its deprotonation product.

Added by Miriam M.

Organic Chemistry

Janice Gorzynski Smith 4th Edition

Instant Answer

Solved by Expert Lottie Adams

01/04/2022

Step 1

The thiazolium ring is the site where TPP can be deprotonated by base. Now, let's assign formal charges to the atoms in TPP: In the thiazolium ring, the nitrogen atom has a positive charge (+1) because it has lost a proton. In the thiazole ring, the nitrogen Show more…

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Thiamin diphosphate (TPP), a derivative of vitamin $B_{1}$ required for glucose metabolism, is a weak acid that can be deprotonated by base. Assign formal charges to the appropriate atoms in both TPP and its deprotonation product.