Question

This question examines the effect of introducing an aliphatic alcohol into the molecule as per a phase 1 reaction. You will need to design and draw a derivative of the material in molinspiration to answer this question. By making sensible modifications to the structure above in Q19, probe the effect of the following modifications on the topological polar surface area and complete the following sentence. Give both a general answer (ie increase/decrease TPSA) and a quantitative change observed (the calculated difference in tPSA). Give your answer as a whole number. The introduction of an aliphatic alcohol Answer Question 21 Å2. eg, if you find that an alcohol decreases PSA by 17 Å2, format your answer exactly as follows: decreases the PSA by 17 eg, if you find that an alcohol increases PSA by 17 Å2, format your answer exactly as follows: increases the PSA by 17 You can copy the bolded text above and change the number to ensure that you do not make errors in syntax.

          This question examines the effect of introducing an aliphatic alcohol into the molecule as per a phase 1 reaction. You will need to design and draw a derivative of the material in molinspiration to answer this question.
By making sensible modifications to the structure above in Q19, probe the effect of the following modifications on the topological polar surface area and complete the following sentence. Give both a general answer (ie increase/decrease TPSA) and a quantitative change observed (the calculated difference in tPSA). Give your answer as a whole number.
The introduction of an aliphatic alcohol Answer Question 21
 Å2.
eg, if you find that an alcohol decreases PSA by 17 Å2, format your answer exactly as follows:
decreases the PSA by 17
eg, if you find that an alcohol increases PSA by 17 Å2, format your answer exactly as follows:
increases the PSA by 17
You can copy the bolded text above and change the number to ensure that you do not make errors in syntax.

Added by Jennifer O.

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